反应详情

To a solution of 2,3-dihydroxybenzoic acid (25 g) in ethanol (320 ml) was added concentrated sulfuric acid (1.8 ml), and the mixture was heated under reflux for one day. The reaction mixture was concentrated, poured into water, and the mixture was extracted with ethyl acetate. The organic layer was washed with saturated brine, and dried over sodium sulfate. The solvent was evaporated under reduced pressure. The residue was subjected to normal phase chromatography (elution solvent ethyl acetate) to give the title compound (30 g, 100%).

1. temperaturethe mixture was heated
2. temperatureunder reflux for one day
3. concentrationThe reaction mixture was concentrated
4. additionpoured into water
5. extractionthe mixture was extracted with ethyl acetate
6. washThe organic layer was washed with saturated brine
7. dry with materialdried over sodium sulfate
8. customThe solvent was evaporated under reduced pressure
9. washThe residue was subjected to normal phase chromatography (elution solvent ethyl acetate)