HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 383912Generated: October 25, 2026
Hydrochloric Acid → 2-Chloro-5-phenylthiazole-4-carboxylic acid
https://huagongshe.com/reaction/383912
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Potassium Hydroxide | HCID 14797 | — |
| Reactant | Ethyl 2-chloro-5-phenylthiazole-4-carboxylate | HCID 59291332 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 2-Chloro-5-phenylthiazole-4-carboxylic acid | HCID 21651637 | — |
Reaction Steps
To a solution of ethyl 2-chloro-5-phenylthiazole-4-carboxylate in THF was added a 1 M aqueous KOH solution, followed by stirring at 60° C. for 30 minutes. To the reaction mixture was added 1 M hydrochloric acid, and the solid precipitated was collected by filtration to obtain 2-chloro-5-phenylthiazole-4-carboxylic acid as a white solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08367696B2 |
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| Source dataset | uspto-grants-2013_02 |
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| ORD ID | ord-04fa5b16812c41a681063f426068f445 |
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| Source note | uspto-grants-2013_02 |
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