Hydrochloric Acid → 2-Chloro-5-phenylthiazole-4-carboxylic acid

HRID 383912Notes

Reaction equation

HRID 383912 reaction equation
[Cl:1][C:2]1[S:3][C:4]([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)=[C:5]([C:7]([O:9]CC)=[O:8])[N:6]=1.[OH-].[K+].Cl>C1COCC1>[Cl:1][C:2]1[S:3][C:4]([C:12]2[CH:13]=[CH:14][CH:15]=[CH:16][CH:17]=2)=[C:5]([C:7]([OH:9])=[O:8])[N:6]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14797Potassium HydroxideHCID 59291332Ethyl 2-chloro-5-phenylthiazole-4-carboxylate

Product 1

HCID 216516372-Chloro-5-phenylthiazole-4-carboxylic acid

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Conditions

Temperature
60 °C

Procedure

To a solution of ethyl 2-chloro-5-phenylthiazole-4-carboxylate in THF was added a 1 M aqueous KOH solution, followed by stirring at 60° C. for 30 minutes. To the reaction mixture was added 1 M hydrochloric acid, and the solid precipitated was collected by filtration to obtain 2-chloro-5-phenylthiazole-4-carboxylic acid as a white solid.

Workup

  1. customthe solid precipitated
  2. filtrationwas collected by filtration

Sources & evidence

ORD record
ord-04fa5b16812c41a681063f426068f445
Source dataset
uspto-grants-2013_02
Patent number
US08367696B2

Reaction notes

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