Aluminium lithium hydride → HCID 59291451, compound

HRID 383915Notes

Reaction equation

HRID 383915 reaction equation
[H-].[H-].[H-].[H-].[Li+].[Al+3].[C:7]1([C:13]2[S:14][CH:15]=[CH:16][C:17]=2[NH:18][C:19](=O)OC(C)(C)C)[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1>C1COCC1>[CH3:19][NH:18][C:17]1[CH:16]=[CH:15][S:14][C:13]=1[C:7]1[CH:8]=[CH:9][CH:10]=[CH:11][CH:12]=1

Participants

4

Reactant 2

HCID 21226445Aluminium lithium hydrideHCID 21631641HCID 21631641, compound

Product 1

HCID 59291451HCID 59291451, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent2×

Procedure

To a suspension of LAH in THF was added a solution of tert-butyl (2-phenyl-3-thienyl)carbamate in THF, followed by stirring at room temperature for 30 minutes and the stirring at 70° C. for 4 hours. After cooling at room temperature, Na2SO4.10H2O was added thereto, followed by stirring at room temperature for 30 minutes. The reaction mixture was filtered and concentrated under reduced pressure to obtain 3-methylamino-2-phenylthiophene as a colorless oily substance.

Workup

  1. waitthe stirring at 70° C. for 4 hours
  2. temperatureAfter cooling at room temperature
  3. stirringby stirring at room temperature for 30 minutes
  4. filtrationThe reaction mixture was filtered
  5. concentrationconcentrated under reduced pressure

Sources & evidence

ORD record
ord-c621fae406d84f158888db887b84d6e1
Source dataset
uspto-grants-2013_02
Patent number
US08367696B2

Reaction notes

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