Aluminium lithium hydride → HCID 59291599, compound

HRID 383921Notes

Reaction equation

HRID 383921 reaction equation
[H-].[H-].[H-].[H-].[Li+].[Al+3].[C:7]1([CH2:13][CH2:14][CH:15]2[N:20]3[CH2:21][CH2:22][CH:17]([C:18](=[O:23])[CH2:19]3)[CH2:16]2)[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1>C(OCC)C.C1COCC1>[C:7]1([CH2:13][CH2:14][CH:15]2[N:20]3[CH2:21][CH2:22][CH:17]([CH:18]([OH:23])[CH2:19]3)[CH2:16]2)[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1

Participants

5

Reactant 2

HCID 21226445Aluminium lithium hydrideHCID 220975616-(2-Phenylethyl)quinuclidin-3-one

Product 1

HCID 59291599HCID 59291599, compound

Reagents, catalysts & solvents 2

HCID 3283Diethyl EtherSolventHCID 8028TetrahydrofuranSolvent

Procedure

To a suspension of LAH in diethyl ether was added a solution of 6-(2-phenylethyl)quinuclidin-3-one in THF, followed by heating under reflux for 4 hours. To the reaction mixture was added Na2SO4.10H2O, followed by stirring at room temperature for overnight. The reaction mixture was filtered, and the filtrate was then concentrated under reduced pressure to obtain 6-(2-phenylethyl)quinuclidin-3-ol as a colorless oil.

Workup

  1. temperatureby heating
  2. temperatureunder reflux for 4 hours
  3. filtrationThe reaction mixture was filtered
  4. concentrationthe filtrate was then concentrated under reduced pressure

Sources & evidence

ORD record
ord-b7f280dee36f47fb972f592654a4450e
Source dataset
uspto-grants-2013_02
Patent number
US08367696B2

Reaction notes

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