Ethyl 4-(2-chloroethyl)hexahydro-1-(phenylmethyl)-1H-azepine-4-carboxylate → HCID 86641067, compound

HRID 383947Notes

Reaction equation

HRID 383947 reaction equation
[CH2:1]([N:8]1[CH2:14][CH2:13][CH2:12][C:11]([CH2:20][CH2:21][Cl:22])([C:15]([O:17][CH2:18][CH3:19])=[O:16])[CH2:10][CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1>CC#N>[Cl-:22].[CH2:1]([N+:8]12[CH2:21][CH2:20][C:11]([C:15]([O:17][CH2:18][CH3:19])=[O:16])([CH2:10][CH2:9]1)[CH2:12][CH2:13][CH2:14]2)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

3

Reactant 1

HCID 59291310Ethyl 4-(2-chloroethyl)hexahydro-1-(phenylmethyl)-1H-azepine-4-carboxylate

Product 1

HCID 86641067HCID 86641067, compoundYield 100%

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

A solution of ethyl 1-benzyl-4-(2-chloroethyl)azepane-4-carboxylate (4.1 g) in MeCN (200 mL) was stirred at 40° C. for 10 hours. The reaction mixture was concentrated under reduced pressure to obtain 1-benzyl-5-(ethoxycarbonyl)-1-azoniabicyclo[3.2.2]nonane chloride (4.1 g) as a colorless oily substance.

Workup

  1. concentrationThe reaction mixture was concentrated under reduced pressure

Sources & evidence

ORD record
ord-61abf6fcafcb4998ac791364c8ce26fd
Source dataset
uspto-grants-2013_02
Patent number
US08367696B2

Reaction notes

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