Methyl iodide → HCID 68593328, compound

HRID 383950Notes

Reaction equation

HRID 383950 reaction equation
[C:1]1([C:7]2[S:8][CH:9]=[CH:10][C:11]=2[NH:12][C:13](=[O:24])[O:14][CH2:15][CH:16]2[CH:21]3[CH2:22][CH2:23][N:18]([CH2:19][CH2:20]3)[CH2:17]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[I:25][CH3:26]>CCOC(C)=O>[I-:25].[CH3:26][N+:18]12[CH2:19][CH2:20][CH:21]([CH2:22][CH2:23]1)[CH:16]([CH2:15][O:14][C:13](=[O:24])[NH:12][C:11]1[CH:10]=[CH:9][S:8][C:7]=1[C:1]1[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1)[CH2:17]2

Participants

4

Reactant 2

HCID 6328Methyl iodideHCID 59291570HCID 59291570, compound

Product 1

HCID 68593328HCID 68593328, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

To a solution of 1-azabicyclo[2.2.2]oct-3-ylmethyl (2-phenyl-3-thienyl)carbamate (100 mg) in EtOAc (2 mL) was added iodomethane (36 μL) at room temperature, followed by stirring for overnight. The reaction mixture was filtered, then concentrated under reduced pressure, and freeze-dried to obtain 1-methyl-3-({[(2-phenyl-3-thienyl)carbamoyl]oxy}methyl)-1-azoniabicyclo[2.2.2]octane iodide (88 mg) as a yellow amorphous substance.

Workup

  1. filtrationThe reaction mixture was filtered
  2. concentrationconcentrated under reduced pressure
  3. customfreeze-dried

Sources & evidence

ORD record
ord-ba8504a93653440d9fa9d9573e568491
Source dataset
uspto-grants-2013_02
Patent number
US08367696B2

Reaction notes

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