Water → HCID 22412626, compound

Temperature

75 °C

a 500-mL, one-necked, round-bottom flask equipped with a magnetic stirrer was charged with 1,6-hexanediol (6.00 g), potassium tert-butoxide (5.413 g) at room temperature. The reaction mixture was stirred for one hour, and then 1-iodopropane (8.63 g) was added. The reaction mixture was heated to 70-80° C. and stirred overnight. The progress of reaction was monitored by TLC (Note 1). After completion of the reaction, water was added to the reaction mixture, and extracted with ethyl acetate (2×100 mL). The combined organic layers were concentrated in vacuo to get the crude product. The crude product was dissolved in dichloromethane and washed with water, and then brine, dried over sodium sulfate. The organic layer was concentrated in vacuo to get the crude product. The crude product was purified by column chromatography using 230-400 mesh silica gel. A solvent gradient of ethyl acetate in hexanes (10-45%) was used to elute the product from the column. All fractions containing the desired pure product were combined and concentrated in vacuo to give pure 6-propyloxy-1-hexanol (lot D-1029-048, 1.9 g, 25%) Completion of the reaction was monitored by thin layer chromatography (TLC); (eluent: 60% ethyl acetate in hexanes).

1. customa 500-mL, one-necked, round-bottom flask equipped with a magnetic stirrer
2. stirringstirred overnight
3. customThe progress of reaction
4. additionwas added to the reaction mixture
5. extractionextracted with ethyl acetate (2×100 mL)
6. concentrationThe combined organic layers were concentrated in vacuo
7. customto get the crude product
8. washwashed with water
9. dry with materialbrine, dried over sodium sulfate
10. concentrationThe organic layer was concentrated in vacuo
11. customto get the crude product
12. customThe crude product was purified by column chromatography
13. washto elute the product from the column
14. additionAll fractions containing the desired pure product
15. concentrationconcentrated in vacuo

ORD record

ord-9fcbb876255b4e4c83013472967beebc

Source dataset

uspto-grants-2013_02

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US08367705B2