Hydrazine hydrate (1:1) → 4-iodo-5-methyl-1H-pyrazolo[3,4-b]pyridine

HRID 384083Notes

Reaction equation

HRID 384083 reaction equation
F[C:2]1[C:7]([CH:8]=O)=[C:6]([I:10])[C:5]([CH3:11])=[CH:4][N:3]=1.O.[NH2:13][NH2:14]>O1CCOCC1>[I:10][C:6]1[C:5]([CH3:11])=[CH:4][N:3]=[C:2]2[NH:13][N:14]=[CH:8][C:7]=12

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 10264818HCID 10264818, compound

Product 1

HCID 579696604-iodo-5-methyl-1H-pyrazolo[3,4-b]pyridine

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

2-fluoro-4-iodo-5-methyl-pyridine-3-carbaldehyde (510 mg, 1.924 mmol) was dissolved in dry Dioxane (10 mL) and Hydrazine monohydrate (288.9 mg, 280.8 μL, 5.772 mmol) was added in one portion

Sources & evidence

ORD record
ord-365ac11ddf784ff29d4198631c040ed1
Source dataset
uspto-grants-2013_02
Patent number
US08367697B2

Reaction notes

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