HCID 86641942, compound → HCID 67272423, compound

HRID 384119Notes

Reaction equation

HRID 384119 reaction equation
Cl[C:2]1[N:7]=[C:6]([CH2:8][OH:9])[C:5]([O:10][C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)=[CH:4][CH:3]=1>C(O)C.[C].[Pd]>[O:10]([C:5]1[C:6]([CH2:8][OH:9])=[N:7][CH:2]=[CH:3][CH:4]=1)[C:11]1[CH:12]=[CH:13][CH:14]=[CH:15][CH:16]=1

Participants

4

Reactant 1

HCID 86641942HCID 86641942, compound

Product 1

HCID 67272423HCID 67272423, compound

Reagents, catalysts & solvents 2

HCID 178418390HCID 178418390, compoundCatalystHCID 702EthanolSolvent

Procedure

To a solution of (6-chloro-3-phenoxypyridin-2-yl)methanol (88 mg) in ethanol (1.5 ml), 10 mg of 10% palladium-carbon catalyst was added, and the reaction solution was stirred for 20 hours under hydrogen atmosphere. The catalyst was filtered off through Celite, and the filtrate was distilled off under reduced pressure to afford the title compound as a yellow solid.

Workup

  1. filtrationThe catalyst was filtered off through Celite
  2. distillationthe filtrate was distilled off under reduced pressure

Sources & evidence

ORD record
ord-bd62ea0b8b5c446fa104de0383a94650
Source dataset
uspto-grants-2013_02
Patent number
US08367708B2

Reaction notes

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