反应详情

To a solution of (3-phenoxyphenyl)acetic acid (1.157 g) in tetrahydrofuran (23 ml), 6.5 ml of borane-tetrahydrofuran complex (1.17M tetrahydrofuran solution) was added, and the reaction solution was stirred at room temperature for 2 hours. To the reaction solution was added water, and the mixture was extracted with chloroform and dried over anhydrous sodium sulfate. The solvent was distilled off under reduced pressure, and the residue obtained was purified by silica gel column chromatography (eluent: ethyl acetate/hexane (10:90-80/20)) to afford the title compound as a colorless oil.

1. extractionthe mixture was extracted with chloroform
2. dry with materialdried over anhydrous sodium sulfate
3. distillationThe solvent was distilled off under reduced pressure
4. customthe residue obtained
5. customwas purified by silica gel column chromatography (eluent: ethyl acetate/hexane (10:90-80/20))