反应详情

温度

0 °C

To a stirring solution of 2-Isopropyl-4-methoxy-5-piperazin-1-yl-phenol (0.47 g, 1.88 mmol) in dichloromethane at 0° C. under nitrogen was added triethylamine (0.26 mL, 1.89 mmol), followed by methanesulfonyl chloride (0.15 mL, 1.89 mmol). The reaction mixture was stirred at 0° C. for five minutes, and then allowed to warm to room temperature. The reaction mixture was partitioned between dichloromethane and water, and the organic layer was separated, washed with water, dried (MgSO4), filtered, and evaporated under reduced pressure. The residue was purified via flash chromatography (hexanes:EtOAc 3:2) to afford 0.1 g (16%) of 2-Isopropyl-5-(4-methanesulfonyl-piperazin-1-yl)-4-methoxy-phenol as an oil.

1. temperatureto warm to room temperature
2. customThe reaction mixture was partitioned between dichloromethane and water
3. customthe organic layer was separated
4. washwashed with water
5. dry with materialdried (MgSO4)
6. filtrationfiltered
7. customevaporated under reduced pressure
8. customThe residue was purified via flash chromatography (hexanes:EtOAc 3:2)