Hydrochloric Acid → HCID 178479551, compound

Participants

Reaction Steps

A suspension of 1.64 g (3.48 mmol) of 4-{3-[3-(2-chloro-4-trifluoromethylphenyl)ureido]-5-fluorobenzylamino}-1H-pyrazole-3-carboxamide in 50 ml of ethanol is stirred at ambient temperature under an argon atmosphere. Then 35 ml (35 mmol) of a solution of hydrochloric acid in diethyl ether (1 N) are added dropwise. The reaction medium becomes a clear solution. After stirring for 10 hours at ambient temperature, the solvents are evaporated using a rotary evaporator under reduced pressure. The residue obtained is stirred in 50 ml of diethyl ether for 30 minutes.

Provenance & Evidence