Hydrochloric Acid → HCID 178479551, compound

HRID 384232Notes

Reaction equation

HRID 384232 reaction equation
[Cl:1][C:2]1[CH:7]=[C:6]([C:8]([F:11])([F:10])[F:9])[CH:5]=[CH:4][C:3]=1[NH:12][C:13](=[O:32])[NH:14][C:15]1[CH:16]=[C:17]([CH:28]=[C:29]([F:31])[CH:30]=1)[CH2:18][NH:19][C:20]1[C:21]([C:25]([NH2:27])=[O:26])=[N:22][NH:23][CH:24]=1.Cl>C(O)C.C(OCC)C>[ClH:1].[Cl:1][C:2]1[CH:7]=[C:6]([C:8]([F:10])([F:11])[F:9])[CH:5]=[CH:4][C:3]=1[NH:12][C:13](=[O:32])[NH:14][C:15]1[CH:16]=[C:17]([CH:28]=[C:29]([F:31])[CH:30]=1)[CH2:18][NH:19][C:20]1[C:21]([C:25]([NH2:27])=[O:26])=[N:22][NH:23][CH:24]=1

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 178513848HCID 178513848, compound

Product 1

HCID 178479551HCID 178479551, compound

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 3283Diethyl EtherSolvent2×

Procedure

A suspension of 1.64 g (3.48 mmol) of 4-{3-[3-(2-chloro-4-trifluoromethylphenyl)ureido]-5-fluorobenzylamino}-1H-pyrazole-3-carboxamide in 50 ml of ethanol is stirred at ambient temperature under an argon atmosphere. Then 35 ml (35 mmol) of a solution of hydrochloric acid in diethyl ether (1 N) are added dropwise. The reaction medium becomes a clear solution. After stirring for 10 hours at ambient temperature, the solvents are evaporated using a rotary evaporator under reduced pressure. The residue obtained is stirred in 50 ml of diethyl ether for 30 minutes.

Workup

  1. stirringAfter stirring for 10 hours at ambient temperature
  2. customthe solvents are evaporated
  3. customa rotary evaporator under reduced pressure
  4. customThe residue obtained

Sources & evidence

ORD record
ord-86bc572ad5514e4192640ea56bec927e
Source dataset
uspto-grants-2013_02
Patent number
US08367715B2

Reaction notes

Loading…