反应详情

A solution of 15 g (110.2 mmol) of 5-fluoro-3-cyanoaniline in 150 ml of tetrahydrofuran is stirred at ambient temperature under an argon atmosphere. Next, 17.5 ml (121.22 mmol) of 2-chloro-4-trifluoromethylphenylisocyanate are added. The reaction medium is heated at reflux for 3 hours then concentrated to dryness using a rotary evaporator. The solid residue obtained is recrystallized at high temperature in 60 ml of ethyl acetate in order to give 33.25 g of 1-(2-chloro-4-trifluoromethylphenyl)-3-(3-cyano-5-fluorophenyl)urea in the form of a white solid.

1. temperatureThe reaction medium is heated
2. temperatureat reflux for 3 hours
3. concentrationthen concentrated to dryness
4. customa rotary evaporator
5. customThe solid residue obtained
6. customis recrystallized at high temperature in 60 ml of ethyl acetate in order