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N-(5-nitro-2-(2-(pyrrolidin-1-yl)ethoxy)phenyl)acetamide → N-(5-amino-2-(2-(pyrrolidin-1-yl)ethoxy)phenyl)acetamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | N-(5-nitro-2-(2-(pyrrolidin-1-yl)ethoxy)phenyl)acetamide | HCID 58098809 | — |
| 触媒 | Palladium | HCID 23938 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 生成物 | N-(5-amino-2-(2-(pyrrolidin-1-yl)ethoxy)phenyl)acetamide | HCID 58098633 | 98.4% |
反応手順
To a solution of N-(5-nitro-2-(2-(pyrrolidin-1-yl)ethoxy)phenyl)acetamide (430 mg) in EtOH (10 mL) was added Pd/C (200 mg) and was charged with H2 (1 atm). After stirring for 3 h, Pd/C was removed by filtration and the filtrate was concentrated to give N-(5-amino-2-(2-(pyrrolidin-1-yl)ethoxy)phenyl)acetamide (380 mg).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08367689B2 |
| 出典データセット | uspto-grants-2013_02 |
| ORD ID | ord-d1633ed141fa4999a8ebff19c862db2f |
| 出典メモ | uspto-grants-2013_02 |