1,2-Dimethoxyethane → 2-Hydroxy-1-[4-(2-{2-hydroxy-3-[(2-hydroxy-3-{2-[4-(2-hydroxy-2-methylpropionyl)-phenoxy]ethoxy}propyl)-(3-hydroxypropyl)amino]-propoxy}ethoxy)phenyl]-2-methylpropan-1-one

Participants

Reaction Steps

To a mixture of 2.22 g (29.6 mmol) of 3-amino-1-propanol in 20 ml of 1,2-dimethoxyethane and 40 ml of 2-propanol is added a solution of 11.57 g (41.3 mmol) of the compound of Example 1A in 20 ml of 1,2-dimethoxyethane. The mixture is heated at reflux overnight. Solvent is evaporated to afford a mixture of the title compounds.

Provenance & Evidence