Bromine → HCID 68861002, compound

Participants

Reaction Steps

A solution of 10 g of bromine in 25 ml of 1,2-dichlorobenzene is added drop wise at room temperature to 13.0 g (0.0509 mol) of crude 1-[4-(2-bromoethyl)phenyl]-2-methylpropan-1-one that is dissolved in 100 ml of 1,2-dichlorobenzene. The reaction mixture is stirred overnight, and then poured into a 5% sodium thiosulfate solution. The mixture is stirred for 30 minutes, and the organic layer is washed with 5% sodium thiosulfate solution, sodium bicarbonate solution, and distilled water. The organic layer is passed through a pad of silica gel and eluted with 9:1 heptane:ethyl acetate to give, after concentration, 7.5 g (55% yield) of 2-bromo-1-[4-(2-bromoethyl)phenyl]-2-methylpropan-1-one.

Provenance & Evidence