反应详情

温度

50 °C

In a 5 mL volume glass vessel equipped with a stirrer and a thermometer were placed 0.5 g (1.9 mmol) of 6-methoxy-7-(3-chloropropoxy)quinazolin-4-one prepared by procedures similar to those of Reference Example V-1, 0.81 g (9.5 mmol) of piperidine, and 4.8 mL (19 mmol) of aqueous sodium hydroxide solution (4.0 mol/L). The resulting mixture was stirred at 50° C. for 5 hours. After the reaction was complete, the reaction mixture was analyzed by high performance liquid chromatography (absolute quantitative analysis). There was produced 0.51 g (reaction yield: 85%) of 6-methoxy-7-(3-piperidinopropoxy)-quinazolin-4-one.

1. customIn a 5 mL volume glass vessel equipped with a stirrer