Tetrahydro-4H-pyran-4-ol → 3-Bromo-2-methyl-6-(tetrahydro-pyran-4-yloxy)-pyridine

HRID 384876Notes

Reaction equation

HRID 384876 reaction equation
[Br:1][C:2]1[C:3]([CH3:9])=[N:4][C:5]([OH:8])=[CH:6][CH:7]=1.[O:10]1[CH2:15][CH2:14][CH:13](O)[CH2:12][CH2:11]1>>[Br:1][C:2]1[C:3]([CH3:9])=[N:4][C:5]([O:8][CH:13]2[CH2:14][CH2:15][O:10][CH2:11][CH2:12]2)=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 74956Tetrahydro-4H-pyran-4-olHCID 178433439HCID 178433439, compound

Product 1

HCID 684086383-Bromo-2-methyl-6-(tetrahydro-pyran-4-yloxy)-pyridine

Procedure

The title compound was prepared from 3-bromo-6-hydroxy-2-methylpyridine and tetrahydro-4H-pyran-4-ol in analogy to Example 9c): colorless solid.

Sources & evidence

ORD record
ord-566bea69afd14365b481ee4e93d62926
Source dataset
uspto-grants-2013_02
Patent number
US08367838B2

Reaction notes

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