Tetrahydro-4H-pyran-4-ol → 5-Bromo-4-methyl-2-(oxan-4-yloxy)pyridine

HRID 384880Notes

Reaction equation

HRID 384880 reaction equation
[Br:1][C:2]1[C:3]([CH3:9])=[CH:4][C:5]([OH:8])=[N:6][CH:7]=1.[O:10]1[CH2:15][CH2:14][CH:13](O)[CH2:12][CH2:11]1>>[Br:1][C:2]1[C:3]([CH3:9])=[CH:4][C:5]([O:8][CH:13]2[CH2:14][CH2:15][O:10][CH2:11][CH2:12]2)=[N:6][CH:7]=1

Participants

3

Reactant 2

HCID 74956Tetrahydro-4H-pyran-4-olHCID 178429280HCID 178429280, compound

Product 1

HCID 684120785-Bromo-4-methyl-2-(oxan-4-yloxy)pyridine

Procedure

The title compound was prepared from 5-bromo-2-hydroxy-4-methylpyridine and tetrahydro-4H-pyran-4-ol in analogy to Example 9c): colorless solid.

Sources & evidence

ORD record
ord-59272bbec2574b2890837d1c23b11254
Source dataset
uspto-grants-2013_02
Patent number
US08367838B2

Reaction notes

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