Tetrahydro-4H-pyran-4-ol → 5-Bromo-2-(tetrahydro-2H-pyran-4-yloxy)pyridine

HRID 384881Notes

Reaction equation

HRID 384881 reaction equation
[Br:1][C:2]1[CH:3]=[CH:4][C:5]([OH:8])=[N:6][CH:7]=1.[O:9]1[CH2:14][CH2:13][CH:12](O)[CH2:11][CH2:10]1>>[Br:1][C:2]1[CH:3]=[CH:4][C:5]([O:8][CH:12]2[CH2:13][CH2:14][O:9][CH2:10][CH2:11]2)=[N:6][CH:7]=1

Participants

3

Reactant 2

HCID 74956Tetrahydro-4H-pyran-4-olHCID 178515818HCID 178515818, compound

Product 1

HCID 219143915-Bromo-2-(tetrahydro-2H-pyran-4-yloxy)pyridine

Procedure

The title compound was prepared from 5-bromo-2-hydroxypyridine and tetrahydro-4H-pyran-4-ol in analogy to Example 9c): colorless solid.

Sources & evidence

ORD record
ord-b2fba64d1c2340bc8d8dcdb31376cb37
Source dataset
uspto-grants-2013_02
Patent number
US08367838B2

Reaction notes

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