反应详情

An amount of 0.21 gm of 2-(2-methoxy-4-methylmercapto-phenyl)-5H-imidazo[4,5-d]pyridazin-4-one is suspended in 10 ml of glacial acetic acid and mixed with 0.08 ml of 30% hydrogen peroxide. The mixture is stirred for 24 hours at ambient temperature and poured onto 20 ml of ice water. It is then stirred until a precipitate has formed. This is subjected to suction filtration and purified by chromatography on silica gel [eluant: methylene chloride/ethanol (100:0 to 100:3)].

1. stirringIt is then stirred until a precipitate
2. customhas formed
3. filtrationThis is subjected to suction filtration
4. custompurified by chromatography on silica gel [eluant: methylene chloride/ethanol (100:0 to 100:3)]