Hydrogen Peroxide → HCID 178418521, compound

HRID 3849Notes

Reaction equation

HRID 3849 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[C:7]([S:9][CH3:10])[CH:6]=[CH:5][C:4]=1[C:11]1[N:12]=[C:13]2[C:18](=[O:19])[NH:17][NH:16][CH:15]=[C:14]2[N:20]=1.[OH:21]O>C(O)(=O)C>[CH3:1][O:2][C:3]1[CH:8]=[C:7]([S:9]([CH3:10])=[O:21])[CH:6]=[CH:5][C:4]=1[C:11]1[N:12]=[C:13]2[C:18](=[O:19])[NH:17][NH:16][CH:15]=[C:14]2[N:20]=1

Participants

4

Reactant 2

HCID 784Hydrogen PeroxideHCID 178418519HCID 178418519, compound

Product 1

HCID 178418521HCID 178418521, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

An amount of 0.21 gm of 2-(2-methoxy-4-methylmercapto-phenyl)-5H-imidazo[4,5-d]pyridazin-4-one is suspended in 10 ml of glacial acetic acid and mixed with 0.08 ml of 30% hydrogen peroxide. The mixture is stirred for 24 hours at ambient temperature and poured onto 20 ml of ice water. It is then stirred until a precipitate has formed. This is subjected to suction filtration and purified by chromatography on silica gel [eluant: methylene chloride/ethanol (100:0 to 100:3)].

Workup

  1. stirringIt is then stirred until a precipitate
  2. customhas formed
  3. filtrationThis is subjected to suction filtration
  4. custompurified by chromatography on silica gel [eluant: methylene chloride/ethanol (100:0 to 100:3)]

Sources & evidence

ORD record
ord-11a5b9119d9941618a2c6738f74ed215
Source dataset
uspto-grants-1988_02
Patent number
US04722929

Reaction notes

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