Tetrahydro-4H-pyran-4-ol → HCID 68412407, compound

HRID 384952Notes

Reaction equation

HRID 384952 reaction equation
[C:1]([O:5][C:6](=[O:26])[NH:7][CH:8]([C:18]1[CH:23]=[CH:22][C:21]([CH3:24])=[C:20]([F:25])[CH:19]=1)[C:9]([C:11]1[CH:16]=[CH:15][C:14]([OH:17])=[CH:13][CH:12]=1)=[O:10])([CH3:4])([CH3:3])[CH3:2].[O:27]1[CH2:32][CH2:31][CH:30](O)[CH2:29][CH2:28]1>>[C:1]([O:5][C:6](=[O:26])[NH:7][CH:8]([C:18]1[CH:23]=[CH:22][C:21]([CH3:24])=[C:20]([F:25])[CH:19]=1)[C:9](=[O:10])[C:11]1[CH:16]=[CH:15][C:14]([O:17][CH:30]2[CH2:31][CH2:32][O:27][CH2:28][CH2:29]2)=[CH:13][CH:12]=1)([CH3:4])([CH3:2])[CH3:3]

Participants

3

Reactant 2

HCID 74956Tetrahydro-4H-pyran-4-olHCID 68408256HCID 68408256, compound

Product 1

HCID 68412407HCID 68412407, compound

Procedure

The title compound was prepared from rac-[1-(3-fluoro-4-methyl-phenyl)-2-(4-hydroxy-phenyl)-2-oxo-ethyl]-carbamic acid tert-butyl ester and tetrahydro-4H-pyran-4-ol in analogy to Example 9c): MS (ISN): 442.4 (M−H)−.

Sources & evidence

ORD record
ord-da3385e7892f493d8150d850f2860f49
Source dataset
uspto-grants-2013_02
Patent number
US08367838B2

Reaction notes

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