3-(Dimethylamino)benzeneboronic acid → HCID 68408636, compound

HRID 384958Notes

Reaction equation

HRID 384958 reaction equation
[C:1]([O:5][C:6](=[O:26])[NH:7][CH:8]([C:18]1[CH:23]=[CH:22][C:21]([Cl:24])=[C:20]([Cl:25])[CH:19]=1)[C:9]([C:11]1[CH:16]=[CH:15][C:14](I)=[CH:13][CH:12]=1)=[O:10])([CH3:4])([CH3:3])[CH3:2].[CH3:27][N:28]([CH3:38])[C:29]1[CH:30]=[C:31](B(O)O)[CH:32]=[CH:33][CH:34]=1>>[C:1]([O:5][C:6](=[O:26])[NH:7][CH:8]([C:18]1[CH:23]=[CH:22][C:21]([Cl:24])=[C:20]([Cl:25])[CH:19]=1)[C:9]([C:11]1[CH:16]=[CH:15][C:14]([C:33]2[CH:32]=[CH:31][CH:30]=[C:29]([N:28]([CH3:38])[CH3:27])[CH:34]=2)=[CH:13][CH:12]=1)=[O:10])([CH3:4])([CH3:3])[CH3:2]

Participants

3

Reactant 2

HCID 27625273-(Dimethylamino)benzeneboronic acidHCID 68409915Rac-[1-(3,4-dichloro-phenyl)-2-(4-iodo-phenyl)-2-oxo-ethyl]-carbamic acid tert-butyl ester

Product 1

HCID 68408636HCID 68408636, compound

Procedure

The title compound was prepared from rac-[1-(3,4-dichloro-phenyl)-2-(4-iodo-phenyl)-2-oxo-ethyl]-carbamic acid tert-butyl ester and 3-(dimethylamino)phenylboronic acid in analogy to Example 1b): MS (ISP): 499.1 and 501.0 (M+H)+.

Sources & evidence

ORD record
ord-179356e6764b422bb6977b69a01589b5
Source dataset
uspto-grants-2013_02
Patent number
US08367838B2

Reaction notes

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