HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 385016Generated: October 29, 2026
Toluene → 3-Cyano-4-methoxy-5-trifluoromethylbenzoylchloride
https://huagongshe.com/reaction/385016
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Toluene | HCID 1140 | — |
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | 3-Cyano-4-methoxy-5-trifluoromethylbenzoic acid | HCID 68109084 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 3-Cyano-4-methoxy-5-trifluoromethylbenzoylchloride | HCID 86668150 | — |
Reaction Steps
To 3-cyano-4-methoxy-5-trifluoromethylbenzoic acid (8.10 g), toluene (160 mL), N,N-dimethylformamide (5 droplets) and thionyl chloride (4.80 mL) were added, and the mixture was stirred at 60° C. for 16 hours. The solvent was distilled off under reduced pressure and the obtained residue was azeotroped with toluene and then used for the synthesis of (i).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08367843B2 |
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| Source dataset | uspto-grants-2013_02 |
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| ORD ID | ord-3c832a6b2619441497dcd29d1ae1ff0d |
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| Source note | uspto-grants-2013_02 |
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