反应详情

温度

60 °C

To 3-cyano-4-methoxy-5-trifluoromethylbenzoic acid (8.10 g), toluene (160 mL), N,N-dimethylformamide (5 droplets) and thionyl chloride (4.80 mL) were added, and the mixture was stirred at 60° C. for 16 hours. The solvent was distilled off under reduced pressure and the obtained residue was azeotroped with toluene and then used for the synthesis of (i).

1. distillationThe solvent was distilled off under reduced pressure
2. customthe obtained residue was azeotroped with toluene
3. customused for the synthesis of (i)