反应详情

温度

60 °C

To 3-t-butyl-5-cyano-4-methoxybenzoic acid (586 mg), toluene (10 mL), N,N-dimethylformamide (2 droplets) and thionyl chloride (0.27 mL) was added, and the mixture was stirred at 60° C. for 16 hours. The solvent was distilled off under reduced pressure and then azeotroped with toluene to obtain the title compound (630 mg) as a brown oily substance.

1. distillationThe solvent was distilled off under reduced pressure
2. customazeotroped with toluene