反应详情

温度

60 °C

To 3-cyano-5-iodo-4-methoxybenzoic acid (512 mg), toluene (5 mL), N,N-dimethylformamide (1 droplet) and thionyl chloride (0.15 mL) were added, and the mixture was stirred at 60° C. for 15 hours. The solvent was distilled off under reduced pressure and then azeotroped with toluene to obtain the title compound (527 mg) as a pale yellow solid.

1. distillationThe solvent was distilled off under reduced pressure
2. customazeotroped with toluene