HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 385115Generated: October 29, 2026
Toluene → 4-Benzyloxy-3-trifluoromethylbenzoyl chloride
https://huagongshe.com/reaction/385115
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Toluene | HCID 1140 | — |
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | 4-(Benzyloxy)-3-(trifluoromethyl)benzoic acid | HCID 16749023 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 4-Benzyloxy-3-trifluoromethylbenzoyl chloride | HCID 86668175 | — |
Reaction Steps
To 4-benzyloxy-3-trifluoromethylbenzoic acid (444 mg), toluene (5 mL), N,N-dimethylformamide (2 droplets) and thionyl chloride (0.16 mL) were added, and then the mixture was stirred at 60° C. for 20 hours. The solvent was distilled off under reduced pressure and then azeotroped with toluene, and the obtained product was used for the synthesis of (h).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08367843B2 |
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| Source dataset | uspto-grants-2013_02 |
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| ORD ID | ord-f0f8665d587f4bf0a4796929d3797997 |
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| Source note | uspto-grants-2013_02 |
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