反应详情

温度

60 °C

To 4-benzyloxy-3-trifluoromethylbenzoic acid (444 mg), toluene (5 mL), N,N-dimethylformamide (2 droplets) and thionyl chloride (0.16 mL) were added, and then the mixture was stirred at 60° C. for 20 hours. The solvent was distilled off under reduced pressure and then azeotroped with toluene, and the obtained product was used for the synthesis of (h).

1. distillationThe solvent was distilled off under reduced pressure
2. customazeotroped with toluene
3. customthe obtained product was used for the synthesis of (h)