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HRID38512

反应详情

EQUATION

反应方程式

HRID 38512 的结构方程式

REACTANTS

反应物

2
结构：CC(=O)O.N=CN
HCID160693

未命名化合物

结构：CCOC(=O)c1c(N)sc2c1CCN(C(=O)OC(C)(C)C)C2
HCID2794740

6-tert-Butyl 3-ethyl 2-amino-4,7-dihydrothieno[2,3-c]pyridine-3,6(5H)-dicarboxylate

C15H22N2O4S

PRODUCTS

生成物

1
结构：CC(C)(C)OC(=O)N1CCc2c(sc3nc[nH]c(=O)c23)C1
HCID49788562

tert-Butyl 4-oxo-3,5,6,8-tetrahydropyrido[4',3':4,5]thieno[2,3-d]pyrimidine-7(4H)-carboxylate

C14H17N3O3S

收率 88%

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CN(C)C=O
溶剂HCID6228

N,N-Dimethylformamide

C3H7NO

CONDITIONS

反应条件

温度
100 °C

PROCEDURE

实验过程

To a solution of 6-tert-butyl 3-ethyl 2-amino-4,7-dihydrothieno[2,3-c]pyridine-3,6(5H)-dicarboxylate from Example 9A (1.23 kg, 3.77 mol) in DMF (10.3 L) was added formamidine acetate (588 g, 5.65 mol). The mixture was heated to 100° C. overnight. The solvent was removed in vacuo. The residue was stirred with ethyl acetate (3 L) for 2 h. The precipitate was collected by suction filtration and rinsed with ethyl acetate. The solid was dried to yield 1.02 kg (88%) of the title compound.

WORKUP

后处理

  1. customThe solvent was removed in vacuo
  2. filtrationThe precipitate was collected by suction filtration
  3. washrinsed with ethyl acetate
  4. customThe solid was dried