Formaldehyde → HCID 68108710, compound

HRID 385122Notes

Reaction equation

HRID 385122 reaction equation
[S:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[NH:3][CH2:2]1.NC1C=CC=CC=1S.C=O.[CH3:20][O:21][C:22]1[C:30]([C:31]([F:34])([F:33])[F:32])=[CH:29][C:25]([C:26](Cl)=[O:27])=[CH:24][C:23]=1[C:35]([N:37]1[CH2:41][CH2:40][CH2:39][CH2:38]1)=[O:36]>C(Cl)(Cl)Cl.C(N(CC)CC)C>[CH3:20][O:21][C:22]1[C:30]([C:31]([F:34])([F:33])[F:32])=[CH:29][C:25]([C:26]([N:3]2[C:4]3[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=3[S:1][CH2:2]2)=[O:27])=[CH:24][C:23]=1[C:35]([N:37]1[CH2:41][CH2:40][CH2:39][CH2:38]1)=[O:36]

Participants

7

Reactant 4

HCID 712FormaldehydeHCID 87132-AminothiophenolHCID 96588BenzothiazolineHCID 86668177HCID 86668177, compound

Product 1

HCID 68108710HCID 68108710, compound

Reagents, catalysts & solvents 2

HCID 6212ChloroformSolventHCID 8471TriethylamineSolvent

Procedure

2,3-dihydro-1,3-benzothiazole synthesized from 2-aminobenzenethiol (464 mg) and 37% formalin (0.31 mL) in the same manner as in Example 1 was dissolved in chloroform (10 mL), and triethylamine (1.03 mL) and 4-methoxy-3-(pyrrolidine-1-carbonyl)-5-trifluoromethylbenzoyl chloride were added to the solution, and then the mixture was stirred at room temperature for 2 hours. The solvent was distilled off under reduced pressure and water was added, and then the mixture was extracted with ethyl acetate. The organic layer was washed with 1N hydrochloric acid, 1N sodium hydroxide and saturated brine, and then dried over anhydrous sodium sulfate. The solvent was distilled off under reduced pressure and the obtained residue was purified by silica gel column chromatography (n-hexane:ethyl acetate=1:2) to obtain the title compound (778 mg) as a pale yellow amorphous product.

Workup

  1. distillationThe solvent was distilled off under reduced pressure and water
  2. additionwas added
  3. extractionthe mixture was extracted with ethyl acetate
  4. washThe organic layer was washed with 1N hydrochloric acid, 1N sodium hydroxide and saturated brine
  5. dry with materialdried over anhydrous sodium sulfate
  6. distillationThe solvent was distilled off under reduced pressure
  7. customthe obtained residue was purified by silica gel column chromatography (n-hexane:ethyl acetate=1:2)

Sources & evidence

ORD record
ord-6b4440ab3cf4441498a180a47b09f67b
Source dataset
uspto-grants-2013_02
Patent number
US08367843B2

Reaction notes

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