反应详情

A suspension of 1.4 gm of 3-[(2-dimethylamino-4-nitro-benzoyl)-amino]-2-amino-6-methoxy-pyridine in 40 ml of phosphorus oxychloride is refluxed for three hours. The phosphorus oxychloride is evaporated off by about two-thirds, and the residue is poured into water. The solution obtained is made ammoniacal, and the product precipitated is purified over a silica gel column [eluant: methylene chloride/ethanol (100:0 to 100:0.5)].

1. temperatureis refluxed for three hours
2. customThe phosphorus oxychloride is evaporated off by about two-thirds
3. additionthe residue is poured into water
4. customThe solution obtained
5. customthe product precipitated
6. customis purified over a silica gel column [eluant: methylene chloride/ethanol (100:0 to 100:0.5)]