反应详情

14.7 g (82.5 mmol) of 2,6-diethyl-4-methylbenzyl alcohol in 150 ml of hydrobromic acid are stirred at 100° C. for 4 h. After cooling, the mixture is extracted with dichloromethane and the extract is washed with water, dried (magnesium sulphate) and concentrated using a rotary evaporator. Distillation (110° C. bath temperature, 0.3 mbar) gives 17.82 g (89%) of 2,6-diethyl-4-methylbenzyl bromide as a colourless oil. 1H-NMR (400 MHz, CDCl3): δ=1.28 (t, 6H), 2.30 (s, 3H), 2.73 (q, 4H), 4.61 (s, 2H), 6.90 (s,

1. temperatureAfter cooling
2. extractionthe mixture is extracted with dichloromethane
3. washthe extract is washed with water
4. dry with materialdried (magnesium sulphate)
5. concentrationconcentrated
6. customa rotary evaporator
7. distillationDistillation (110° C. bath temperature, 0.3 mbar)