Hydrochloric Acid → HCID 178418554, compound

HRID 3854Notes

Reaction equation

HRID 3854 reaction equation
[CH3:1][N:2]([CH3:23])[C:3]1[CH:8]=[C:7]([N+:9]([O-:11])=[O:10])[CH:6]=[CH:5][C:4]=1[C:12]1[NH:13][C:14]2[C:15]([N:22]=1)=[N:16][C:17]([O:20]C)=[CH:18][CH:19]=2.Cl>>[CH3:1][N:2]([CH3:23])[C:3]1[CH:8]=[C:7]([N+:9]([O-:11])=[O:10])[CH:6]=[CH:5][C:4]=1[C:12]1[N:22]=[C:15]2[NH:16][C:17](=[O:20])[CH2:18][CH:19]=[C:14]2[N:13]=1

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 135323492-(2-Dimethylamino-4-nitro-phenyl)-5-methoxy-imidazo[4,5-b]pyridine

Product 1

HCID 178418554HCID 178418554, compound

Procedure

A quantity of 0.2 gm of 2-(2-dimethylamino-4-nitro-phenyl)-5-methoxy-imidazo[4,5-b]pyridine is heated in a bomb tube to 100° C. for three hours with 5 ml of concentrated hydrochloric acid. The reaction mixture is poured onto about 20 ml of ice, neutralized, and extracted with ethyl acetate. After washing with water and drying with magnesium sulfate, the ethyl acetate phase is evaporated. The residue is crystallized by trituration in ether/petroleum ether.

Workup

  1. extractionneutralized, and extracted with ethyl acetate
  2. washAfter washing with water
  3. dry with materialdrying with magnesium sulfate
  4. customthe ethyl acetate phase is evaporated
  5. customThe residue is crystallized by trituration in ether/petroleum ether

Sources & evidence

ORD record
ord-32e3d902264f4bcabd1c60500c9ad7ca
Source dataset
uspto-grants-1988_02
Patent number
US04722929

Reaction notes

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