3-Amino-4-chlorophenol → HCID 66850362, compound

HRID 38556Notes

Reaction equation

HRID 38556 reaction equation
[Cl:1][C:2]1[C:3]2[C:10]3[CH2:11][CH2:12][N:13](C(OC(C)(C)C)=O)[CH2:14][C:9]=3[S:8][C:4]=2[N:5]=[CH:6][N:7]=1.[NH2:22][C:23]1[CH:24]=[C:25]([OH:30])[CH:26]=[CH:27][C:28]=1[Cl:29]>>[ClH:1].[Cl:29][C:28]1[CH:27]=[CH:26][C:25]([OH:30])=[CH:24][C:23]=1[NH:22][C:2]1[C:3]2[C:10]3[CH2:11][CH2:12][NH:13][CH2:14][C:9]=3[S:8][C:4]=2[N:5]=[CH:6][N:7]=1

Participants

3

Reactant 2

HCID 50700783-Amino-4-chlorophenolHCID 49788563tert-Butyl 4-chloro-5,6-dihydropyrido(4',3':4,5)thieno(2,3-d)pyrimidine-7(8H)-carboxylate

Product 1

HCID 66850362HCID 66850362, compound

Procedure

The title compound was prepared in analogy to Example 65A from tert-butyl 4-chloro-5,8-dihydropyrido[4′,3′:4,5]thieno[2,3-d]pyrimidine-7(6H)-carboxylate from Example 11A (2.16 g, 6.63 mmol) and 3-amino-4-chlorophenol (1.00 g, 6.97 mmol) to yield 2.26 g (87%).

Workup

  1. customto yield 2.26 g (87%)

Sources & evidence

ORD record
ord-a7b81074ba2f433bae78cf4c09923456
Source dataset
uspto-grants-2013_09
Patent number
US08524722B2

Reaction notes

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