反应详情

温度

120 °C

Four grams of 2-(2,4-dimethoxy-phenyl)-imidazo[4,5-b]pyridin-4-oxide is suspended in 40 ml of acetic anhydride and refluxed for 2.75 hours. After cooling the mixture is poured onto 150 ml of ice, 25 ml of 6N hydrochloric acid are added, and the mixture is stirred at 120° C. for 30 minutes. It is cooled to ambient temperature, 50 ml of water are added, and the precipitate is subjected to suction filtration. The product is purified by chromatography on silica gel [eluant: methylene chloride/methanol (100:0 to 100:10)].

1. temperaturerefluxed for 2.75 hours
2. temperatureAfter cooling the mixture
3. additionare added
4. temperatureIt is cooled to ambient temperature
5. filtrationthe precipitate is subjected to suction filtration
6. customThe product is purified by chromatography on silica gel [eluant: methylene chloride/methanol (100:0 to 100:10)]