Hydrogen chloride-ethyl acetate → HCID 68931821, compound

HRID 385620Notes

Reaction equation

HRID 385620 reaction equation
[O:1]1[C:10]2[CH:9]=[C:8]([CH2:11][NH:12][CH:13]3[CH2:18][CH2:17][N:16]([CH2:19][CH2:20][N:21]4[C:30]5[C:25](=[N:26][CH:27]=[C:28]([O:31][CH3:32])[CH:29]=5)[CH:24]=[CH:23][C:22]4=[O:33])[CH:15]([CH3:34])[CH2:14]3)[N:7]=[CH:6][C:5]=2[O:4][CH2:3][CH2:2]1.[ClH:35].C(OCC)(=O)C>C(OCC)(=O)C>[ClH:35].[O:1]1[C:10]2[CH:9]=[C:8]([CH2:11][NH:12][CH:13]3[CH2:18][CH2:17][N:16]([CH2:19][CH2:20][N:21]4[C:30]5[C:25](=[N:26][CH:27]=[C:28]([O:31][CH3:32])[CH:29]=5)[CH:24]=[CH:23][C:22]4=[O:33])[CH:15]([CH3:34])[CH2:14]3)[N:7]=[CH:6][C:5]=2[O:4][CH2:3][CH2:2]1

Participants

4

Reactant 2

HCID 21866389Hydrogen chloride-ethyl acetateHCID 57815365HCID 57815365, compound

Product 1

HCID 68931821HCID 68931821, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

To a solution of 53 mg of 1-(2-(4-((2,3-dihydro(1,4)dioxino(2,3-c)pyridin-7-ylmethyl)amino)-2-methylpiperidin-1-yl)ethyl)-7-methoxy-1,5-naphthyridin-2(1H)-one in 1 mL of ethyl acetate, 0.23 mL of a 4.0 mol/L hydrogen chloride/ethyl acetate solution was added at room temperature, and after stirring, the solid was filtered off to obtain 40 mg of 1-(2-(4-((2,3-dihydro(1,4)dioxino(2,3-c)pyridin-7-ylmethyl)amino)-2-methylpiperidin-1-yl)ethyl)-7-methoxy-1,5-naphthyridin-2(1H)-one hydrochloride as a light yellow solid.

Workup

  1. filtrationthe solid was filtered off

Sources & evidence

ORD record
ord-bbc7e1bae0b64904a9e777e4d7a32eaa
Source dataset
uspto-grants-2013_02
Patent number
US08367831B2

Reaction notes

Loading…