Hydrogen chloride-ethyl acetate → HCID 68925008, compound

HRID 385652Notes

Reaction equation

HRID 385652 reaction equation
[O:1]1[C:10]2[C:5](=[N:6][CH:7]=[C:8]([CH2:11][NH:12][CH:13]3[CH2:18][CH2:17][N:16]([CH2:19][CH2:20][N:21]4[C:30]5[C:25](=[N:26][CH:27]=[C:28]([O:31][CH3:32])[CH:29]=5)[CH:24]=[CH:23][C:22]4=[O:33])[CH2:15][CH2:14]3)[CH:9]=2)[O:4][CH2:3][CH2:2]1.[ClH:34].C(OCC)(=O)C>CO.C(OCC)(=O)C>[ClH:34].[O:1]1[C:10]2[C:5](=[N:6][CH:7]=[C:8]([CH2:11][NH:12][CH:13]3[CH2:18][CH2:17][N:16]([CH2:19][CH2:20][N:21]4[C:30]5[C:25](=[N:26][CH:27]=[C:28]([O:31][CH3:32])[CH:29]=5)[CH:24]=[CH:23][C:22]4=[O:33])[CH2:15][CH2:14]3)[CH:9]=2)[O:4][CH2:3][CH2:2]1

Participants

5

Reactant 2

HCID 21866389Hydrogen chloride-ethyl acetateHCID 57815223HCID 57815223, compound

Product 1

HCID 68925008HCID 68925008, compound

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 8857Ethyl AcetateSolvent

Procedure

In a solution of 134 mg of 1-(2-(4-((2,3-dihydro(1,4)dioxino(2,3-b)pyridin-7-yl)methylamino)piperidin-1-yl)ethyl)-7-methoxy-1,5-naphthyridin-2(1H)-one in 1 mL of methanol and 5 mL of ethyl acetate, 2 mL of 4 mol/L hydrogen chloride/ethyl acetate was added, and the mixture was stirred at room temperature. The solid was filtered off to obtain 159 mg of 1-(2-(4-((2,3-dihydro(1,4)dioxino(2,3-b)pyridin-7-yl)methylamino)piperidin-1-yl)ethyl)-7-methoxy-1,5-naphthyridin-2(1H)-one hydrochloride as a light yellow solid.

Workup

  1. filtrationThe solid was filtered off

Sources & evidence

ORD record
ord-55e1dd023ab24b4a8a8c35eb2ec6222f
Source dataset
uspto-grants-2013_02
Patent number
US08367831B2

Reaction notes

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