5-Bromo-2-nitrothiophene-3-carboxamide → 2-Amino-5-[4-(3-fluorooxetan-3-yl)phenyl]thiophene-3-carboxamide

HRID 385724Notes

Reaction equation

HRID 385724 reaction equation
BrC1SC([N+]([O-])=O)=C(C(N)=O)C=1.[F:13][C:14]1([C:18]2[CH:23]=[CH:22][C:21]([C:24]3[S:28][C:27]([N+:29]([O-])=O)=[C:26]([C:32]([NH2:34])=[O:33])[CH:25]=3)=[CH:20][CH:19]=2)[CH2:17][O:16][CH2:15]1>>[NH2:29][C:27]1[S:28][C:24]([C:21]2[CH:22]=[CH:23][C:18]([C:14]3([F:13])[CH2:15][O:16][CH2:17]3)=[CH:19][CH:20]=2)=[CH:25][C:26]=1[C:32]([NH2:34])=[O:33]

Participants

3

Reactant 2

HCID 534029485-Bromo-2-nitrothiophene-3-carboxamideHCID 595261965-[4-(3-Fluorooxetan-3-yl)phenyl]-2-nitrothiophene-3-carboxamide

Product 1

HCID 595262372-Amino-5-[4-(3-fluorooxetan-3-yl)phenyl]thiophene-3-carboxamide

Procedure

The title compound was prepared according to the general procedure in Intermediate 10 Step 6 using 5-[4-(3-fluorooxetan-3-yl)phenyl]-2-nitrothiophene-3-carboxamide (272 mg, 0.84 mmol) as the starting material.

Sources & evidence

ORD record
ord-0f93a53747d34e559a06631f3480801a
Source dataset
uspto-grants-2013_02
Patent number
US08367706B2

Reaction notes

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