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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 385724Generated: November 1, 2026

5-Bromo-2-nitrothiophene-3-carboxamide → 2-Amino-5-[4-(3-fluorooxetan-3-yl)phenyl]thiophene-3-carboxamide

https://huagongshe.com/reaction/385724

Reaction equation

Participants

RoleNameHCIDCharge
Reactant5-Bromo-2-nitrothiophene-3-carboxamideHCID 53402948—
Reactant5-[4-(3-Fluorooxetan-3-yl)phenyl]-2-nitrothiophene-3-carboxamideHCID 59526196—
Product2-Amino-5-[4-(3-fluorooxetan-3-yl)phenyl]thiophene-3-carboxamideHCID 59526237—

Reaction Steps

The title compound was prepared according to the general procedure in Intermediate 10 Step 6 using 5-[4-(3-fluorooxetan-3-yl)phenyl]-2-nitrothiophene-3-carboxamide (272 mg, 0.84 mmol) as the starting material.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08367706B2
Source datasetuspto-grants-2013_02
ORD IDord-0f93a53747d34e559a06631f3480801a
Source noteuspto-grants-2013_02