5-[6-(1-Hydroxy-1-methylethyl)pyridin-3-yl]-2-nitrothiophene-3-carboxamide → 2-Amino-5-[6-(1-hydroxy-1-methylethyl)pyridin-3-yl]thiophene-3-carboxamide

Participants

Reaction Steps

To 5-[6-(1-hydroxy-1-methylethyl)pyridin-3-yl]-2-nitrothiophene-3-carboxamide (245 mg, 0.80 mmol) in MeOH (20 mL) was added 3% Pt/C doped with 0.6% V (52 mg, 8.0 μmol). The reaction was stirred under a hydrogen balloon at room temperature for 4 h. The solution was diluted with MeOH, filtered through Celite, and evaporated to give the title compound as a gray solid.

Provenance & Evidence