2-Amino-5-(2-fluorophenyl)thiophene-3-carboxamide → 5-(2-Fluorophenyl)-2-{[6-(1-hydroxyethyl)pyridin-2-yl]amino}thiophene-3-carboxamide

HRID 385757Notes

Reaction equation

HRID 385757 reaction equation
Br[C:2]1[N:7]=[C:6]([CH:8]([OH:10])[CH3:9])[CH:5]=[CH:4][CH:3]=1.[NH2:11][C:12]1[S:13][C:14]([C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][C:21]=2[F:26])=[CH:15][C:16]=1[C:17]([NH2:19])=[O:18]>>[F:26][C:21]1[CH:22]=[CH:23][CH:24]=[CH:25][C:20]=1[C:14]1[S:13][C:12]([NH:11][C:2]2[CH:3]=[CH:4][CH:5]=[C:6]([CH:8]([OH:10])[CH3:9])[N:7]=2)=[C:16]([C:17]([NH2:19])=[O:18])[CH:15]=1

Participants

3

Reactant 2

HCID 99646972-Amino-5-(2-fluorophenyl)thiophene-3-carboxamideHCID 110634791-(6-bromopyridin-2-yl)ethanol

Product 1

HCID 251268235-(2-Fluorophenyl)-2-{[6-(1-hydroxyethyl)pyridin-2-yl]amino}thiophene-3-carboxamide

Procedure

The title compound was prepared according to the general procedure in Example 1 using 1-(6-bromopyridin-2-yl)ethanol (65.0 mg, 0.322 mmol) and 2-amino-5-(2-fluorophenyl)thiophene-3-carboxamide (78.0 mg, 0.330 mmol) as the starting materials.

Sources & evidence

ORD record
ord-a2d08cd4bd1f4d6fbbbd906d82ad85da
Source dataset
uspto-grants-2013_02
Patent number
US08367706B2

Reaction notes

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