HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Amino-5-(2-fluorophenyl)thiophene-3-carboxamide → 5-(2-Fluorophenyl)-2-{[6-(1-hydroxyethyl)pyridin-2-yl]amino}thiophene-3-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Amino-5-(2-fluorophenyl)thiophene-3-carboxamide | HCID 9964697 | — |
| Reactant | 1-(6-bromopyridin-2-yl)ethanol | HCID 11063479 | — |
| Product | 5-(2-Fluorophenyl)-2-{[6-(1-hydroxyethyl)pyridin-2-yl]amino}thiophene-3-carboxamide | HCID 25126823 | — |
Reaction Steps
The title compound was prepared according to the general procedure in Example 1 using 1-(6-bromopyridin-2-yl)ethanol (65.0 mg, 0.322 mmol) and 2-amino-5-(2-fluorophenyl)thiophene-3-carboxamide (78.0 mg, 0.330 mmol) as the starting materials.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08367706B2 |
| Source dataset | uspto-grants-2013_02 |
| ORD ID | ord-a2d08cd4bd1f4d6fbbbd906d82ad85da |
| Source note | uspto-grants-2013_02 |