2-Amino-5-phenylthiophene-3-carboxamide → 2-{[5-(1-Hydroxy-1-methylethyl)pyridin-2-yl]amino}-5-phenylthiophene-3-carboxamide

HRID 385758Notes

Reaction equation

HRID 385758 reaction equation
Br[C:2]1[N:7]=[CH:6][C:5]([C:8]([OH:11])([CH3:10])[CH3:9])=[CH:4][CH:3]=1.[NH2:12][C:13]1[S:14][C:15]([C:21]2[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=2)=[CH:16][C:17]=1[C:18]([NH2:20])=[O:19]>>[OH:11][C:8]([C:5]1[CH:4]=[CH:3][C:2]([NH:12][C:13]2[S:14][C:15]([C:21]3[CH:22]=[CH:23][CH:24]=[CH:25][CH:26]=3)=[CH:16][C:17]=2[C:18]([NH2:20])=[O:19])=[N:7][CH:6]=1)([CH3:10])[CH3:9]

Participants

3

Reactant 2

HCID 7039652-Amino-5-phenylthiophene-3-carboxamideHCID 223919732-(6-Bromo-3-pyridyl)-2-propanol

Product 1

HCID 595261542-{[5-(1-Hydroxy-1-methylethyl)pyridin-2-yl]amino}-5-phenylthiophene-3-carboxamide

Procedure

2-{[5-(1-Hydroxy-1-methylethyl)pyridin-2-yl]amino}-5-phenylthiophene-3-carboxamide was prepared using 2-(6-bromopyridin-3-yl)propan-2-ol (79.3 mg, 0.367 mmol) (for preparation, see WO 2004/050024 A2 Example 120 Step A) and 2-amino-5-phenylthiophene-3-carboxamide (80 mg, 0.367 mmol) as the starting materials according the general procedure in Example 1.

Sources & evidence

ORD record
ord-26b07a4a7cbe4fcea01ac56825099e70
Source dataset
uspto-grants-2013_02
Patent number
US08367706B2

Reaction notes

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