1-(2-Pyridyl)piperazine → N-(3,4-Dichlorophenyl)-7-[(2E)-4-(4-pyridin-2-ylpiperazin-1-yl)but-2-enoyl]-5,6,7,8-tetrahydropyrido[4',3':4,5]thieno[2,3-d]pyrimidin-4-amine

Participants

Reaction Steps

To a suspension of Example 59A (80 mg, 0.16 mmol) in DMF (1 mL) was added 1-pyridin-2-ylpiperazine (52 mg, 0.32 mmol), and the mixture was stirred at rt for 3 h and then heated to 50° C. for 4 h. After purification by preparative HPLC, the product crystallized upon trituration with dichloromethane to yield 74 mg (79%) of the title compound.

Provenance & Evidence