反应详情

To a suspension of Example 59A (80 mg, 0.16 mmol) in DMF (1 mL) was added 1-pyridin-2-ylpiperazine (52 mg, 0.32 mmol), and the mixture was stirred at rt for 3 h and then heated to 50° C. for 4 h. After purification by preparative HPLC, the product crystallized upon trituration with dichloromethane to yield 74 mg (79%) of the title compound.

1. temperatureheated to 50° C. for 4 h
2. customAfter purification by preparative HPLC
3. customthe product crystallized upon trituration with dichloromethane