1-Methyloctahydropyrrolo[3,4-B]pyrrole → N-(3,4-Dichlorophenyl)-7-[(2E)-4-(1-methylhexahydropyrrolo[3,4-b]pyrrol-5(1H)-yl)but-2-enoyl]-5,6,7,8-tetrahydropyrido[4',3':4,5]thieno[2,3-d]pyrimidin-4-amine

Participants

Reaction Steps

To a suspension of Example 59A (80 mg, 0.16 mmol) in DMF (1 mL) was added 1-methyloctahydropyrrolo[3,4-b]pyrrole (41 mg, 0.32 mmol), and the mixture was stirred at rt for 20 h. After purification by preparative HPLC, the title compound was crystallized from dichloromethane/petroleum ether to yield 12 mg (14%).

Provenance & Evidence