反应详情

To a suspension of Example 59A (80 mg, 0.16 mmol) in DMF (1 mL) was added 1-methyloctahydropyrrolo[3,4-b]pyrrole (41 mg, 0.32 mmol), and the mixture was stirred at rt for 20 h. After purification by preparative HPLC, the title compound was crystallized from dichloromethane/petroleum ether to yield 12 mg (14%).

1. customAfter purification by preparative HPLC
2. customthe title compound was crystallized from dichloromethane/petroleum ether
3. customto yield 12 mg (14%)